Nanomaterialer

Criteria for grouping of manufactured nanomaterials to facilitate hazard and risk assessment, a systematic review of expert opinions.

With the emergence of nanotechnology the number of manufactured nanomaterials (MNM) in production and use is constantly increasing. Expos...

Landvik, Nina Elisabeth; Skaug, Vidar; Mohr, Benedicte; Verbeek, Jos; Zienolddiny, Shanbeh

Characterization of the proteome and lipidome profiles of human lung cells after low dose and chronic exposure to multiwalled carbon nanotubes

The effects of long-term chronic exposure of human lung cells to multi-walled carbon nanotubes (MWCNT) and their impact upon cellular pro...

Phuyal, Santosh; Kasem, Mayes; Knittelfelder, Oskar; Sharma, Animesh; Fonseca, Davi de Miranda; Vebraite, Vaineta; Shaposhnikov, Sergey; Slupphaug, Geir; Skaug, Vidar; Zienolddiny, Shanbeh

Influence of dispersion medium on nanomaterial-induced pulmonary inflammation and DNA strand breaks: Investigation of carbon black, carbon nanotubes and three titanium dioxide nanoparticles

Intratracheal instillation serves as a model for inhalation exposure. However, for this, materials are dispersed in appropriate media tha...

Hadrup, Niels; Bengtson, Stefan; Jacobsen, Nicklas R. ; Jackson, Petra; Nocun, Marek ; Saber, Anne T.; Jensen, Keld A. ; Wallin, Håkan; Vogel, Ulla

WHO guidelines on protecting workers from potential risks of manufactured nanomaterials

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Multi-walled carbon nanotube-induced genotoxic, inflammatory and pro-fibrotic responses in mice: Investigating the mechanisms of pulmonary carcinogenesis

The International Agency for Research on Cancer has classified one type of multi-walled carbon nanotubes (MWCNTs) as possibly carcinogeni...

Rahman, Luna; Jacobsen, Nicklas Raun; Aziz, Syed Abdul; Wu, Dongmei; Williams, Andrew; Yauk, Carole L.; White, Paul; Wallin, Håkan; Vogel, Ulla; Halappanavar, Sabina

Stat-6 signaling pathway and not Interleukin-1 mediates multi-walled carbon nanotube-induced lung fibrosis in mice: Insights from an adverse outcome pathway framework

Background: The accumulation of MWCNTs in the lung environment leads to inflammation and the development of disease similar to pulmonary ...

Nikota, Jake; Banville, Allyson; Goodwin, Laura Rose; Wu, Dongmei; Williams, Andrew; Yauk, Carole Lynn; Wallin, Håkan; Vogel, Ulla; Halappanavar, Sabina

Effects on human bronchial epithelial cells following low-dose chronic exposure to nanomaterials: A 6-month transformation study

The most plausible exposure route to manufactured nanomaterials (MNM) remains pulmonary inhalation. Yet, few studies have attempted to as...

Phuyal, Santosh; Kasem, Mayes; Rubio, Laura; Karlsson, Hanna; Marcos, Ricard; Skaug, Vidar; Zienolddiny, Shanbeh

In vitro genotoxicity testing of four reference metal nanomaterials, titanium dioxide, zinc oxide, cerium oxide and silver: towards reliable hazard assessment

There is serious concern about the potential harmful effects of certain nanomaterials (NMs), on account of their ability to penetrate cel...

El Yamani, Naouale; Collins, Andrew Richard; Rundén-Pran, Elise; Fjellsbø, Lise Marie; Shaposhnikov, Sergey; Zienolddiny, Shanbeh; Dusinska, Maria

Multi-walled carbon nanotube physicochemical properties predict pulmonary inflammation and genotoxicity

Lung deposition of multi-walled carbon nanotubes (MWCNT) induces pulmonary toxicity. Commercial MWCNT vary greatly in physicochemical pro...

Poulsen, Sarah S.; Jackson, Petra; Kling, Kirsten; Knudsen, Kristina B.; Skaug, Vidar; Kyjovska, Zdenka O.; Thomsen, Birthe L.; Clausen, Per A.; Atluri, Rambabu; Berthing, Trine; Bengtson, Stefan ...

Effects of carbon nanotubes on intercellular communication and involvement of IL-1 genes

An increasing amount of products containing engineered nanoparticles is emerging. Among these particles are carbon nanotubes (CNTs) which...

Arnoldussen, Yke Jildouw; Anmarkrud, Kristine Haugen; Skaug, Vidar; Apte, Ron N.; Haugen, Aage; Zienolddiny, Shanbeh

Carbon Nanotube Emissions from Arc Discharge Production: Classification of Particle Types with Electron Microscopy and Comparison with Direct Reading Techniques

Introduction: An increased production and use of carbon nanotubes (CNTs) is occurring worldwide. In parallel, a growing concern is emergi...

Ludvigsson, Linus; Isaxon, Christina; Nilsson, Patrik T.; Tinnerberg, Hakan; Messing, Maria E.; Rissler, Jenny; Skaug, Vidar; Gudmundsson, Anders; Bohgar, Mats; Hedmer, Maria; Pagels, Joakim

Morphology, chemical composition and nanostructure of single carbon-rich particles studied by transmission electron microscopy: Source apportionment in workroom air of aluminium smelters

Sources of C-rich particles at work places in two aluminium smelters in Norway were studied by transmission electron microscopy and energ...

Weinbruch, Stephan; Benker, Nathalie; Kandler, Konrad; Ebert, Martin; Ellingsen, Dag; Berlinger, Balazs; Thomassen, Yngvar

Detection of multi-walled carbon nanotubes and carbon nanodiscs on workplace surfaces at a small-scale producer

Background: The industrial use of novel-manufactured nanomaterials such as carbon nanotubes and carbon nanodiscs is increasing globally. ...

Hedmer, Maria; Ludvigsson, Linus; Isaxon, Christina; Nilsson, Patrik T.; Skaug, Vidar; Bohgard, Mats; Pagels, Joakim H.; Messing, Maria E.; Tinnerberg, Håkan

Involvement of IL-1 genes in the cellular responses to carbon nanotube exposure

The interleukin-1 (IL-1) family has been implicated in cellular responses to nanoparticles including carbon nanotubes (CNTs). IL-1α and β...

Arnoldussen, Yke Jildouw; Skogstad, Asbjørn; Skaug, Vidar; Kasem, Mayes; Haugen, Aage; Benker, Nathalie; Weinbruch, Stephan; Apte, Ron N.; Zienolddiny, Shanbeh