Genetiske faktorer
Genene har stor betydning for hvordan kroppen er i stand til å bearbeide potensielt farlige stoffer. Noen blir syke ved lave mengder, mens andre tåler mer.
Nytt funn om sammenhengen mellom nattarbeid, døgnrytmegener og brystkreft
Forstyrrelser i døgnrytmen er en av mekanismene som kobler nattarbeid til økt brystkreftrisiko. En ny studie fra Statens arbeidsmiljøinst...
Ny doktorgrad: Genetikk og effekten av mobbing
Mobbing på arbeidsplassen er en form for sosialt stress som kan gi opphav til angst, hjelpeløshet og smerte. Denne avhandlingen adressere...
Hva vet vi om årsakssammenhenger mellom brystkreft og nattarbeid?
Hvorfor er skiftarbeidere som jobber om natten mer utsatte for brystkreft? STAMI bidrar med å undersøke de underliggende biologiske mekan...
Mobbing, genetikk og smerte
Mobbing er et utbredt problem på norske arbeidsplasser, og kan føre til alvorlige helseproblemer – deriblant smerte. Vi vet fra tidligere...
Analysis of parent-of-origin effects on the X chromosome in asian and european orofacial cleft triads identifies associations with DMD, FGF13, EGFL6, and additional loci at Xp22.2
Background: Although both the mother's and father's alleles are present in the offspring, they may not operate at the same level. These p...
Skare, Øivind; Lie, Rolv T.; Haaland, Øystein Ariansen; Gjerdevik, Miriam; Romanowska, Julia; Gjessing, Håkon K.; Jugessur, Astanand
Negative social acts and pain. Evidence of a workplace bullying and 5-HTT genotype interaction
Objectives: Long-term exposure to systematic negative acts at work, usually labeled workplace bullying, is a prevalent problem at many wo...
Jacobsen, Daniel Pitz; Nielsen, Morten Birkeland; Einarsen, Ståle; Gjerstad, Johannes
Medisinsk fødselsregister i miljøovervåkingen - muligheter og begrensninger
Overvåking har vært en prioritert oppgave for Medisinsk fødselsregister helt siden starten i 1967. Denne oversikten dekker miljøovervåkin...
Kristensen, Petter
Sleep quality and methylation status of selected tumor suppressor genes among nurses and midwives
Chronic sleep restriction may affect metabolism, hormone secretion patterns and inflammatory responses. Limited reports suggest also epig...
Bukowska-Damska, Agnieszka; Reszka, Edyta; Kaluzny, Pawel; Wieczorek, Edyta; Przybek, Monika; Zienolddiny, Shanbeh; Peplonska, Beata
Circadian gene methylation in rotating-shift nurses: a cross-sectional study
Investigating the methylation status of the circadian genes may contribute to a better understanding of the shift work-related circadian ...
Reszka, Edyta; Wieczorek, Edyta; Przybek, Monika; Jablonska, Ewa; Kaluzny, Pawel; Bukowska-Damska, Agnieszka; Zienolddiny, Shanbeh; Peplonska, Beata
Genome-wide interaction study of smoking behavior and non-small cell lung cancer risk in Caucasian population
Non-small cell lung cancer is the most common type of lung cancer. Both environmental and genetic risk factors contribute to lung carcino...
Li, Y.; Xiao, X.; Han, Y.; Gorlova, O.; Qian, D.; Leigh, N.; Johansen, J.S.; Barnett, M.; Chen, C.; Goodman, G.; Cox, A. ...
Mechanisms of breast cancer in shift workers: DNA methylation in five core circadian genes in nurses working night shifts
Shift work has been suggested to be associated with breast cancer risk, and circadian disruption in shift workers is hypothesized as one ...
Samulin-Erdem, Johanna Maria; Skare, Øivind; Petersen-Øverleir, Marte; Notø, Heidi Ødegaard; Lie, Jenny-Anne Sigstad; Reszka, Edyta; Peplonska, Beata; Zienolddiny, Shanbeh
Multi-walled carbon nanotube-induced genotoxic, inflammatory and pro-fibrotic responses in mice: Investigating the mechanisms of pulmonary carcinogenesis
The International Agency for Research on Cancer has classified one type of multi-walled carbon nanotubes (MWCNTs) as possibly carcinogeni...
Rahman, Luna; Jacobsen, Nicklas Raun; Aziz, Syed Abdul; Wu, Dongmei; Williams, Andrew; Yauk, Carole L.; White, Paul; Wallin, Håkan; Vogel, Ulla; Halappanavar, Sabina
Influence of catechol-O-methyltransferase Val158Met on fear of pain and placebo analgesia
Higher levels of fear have been shown to partly explain individual differences in placebo analgesic responding. The catechol-Omethyltrans...
Forsberg, June Thorvaldsen; Gjerstad, Johannes; Flaten, Magne; Aslaksen, Per M.
A new approach to chromosome-wide analysis of X-linked markers identifies new associations in Asian and European case-parent triads of orofacial clefts
Background GWAS discoveries on the X-chromosome are underrepresented in the literature primarily because the analytical tools that have b...
Skare, Øivind; Gjessing, Håkon K.; Gjerdevik, Miriam; Haaland, Øystein Ariansen; Romanowska, Julia; Lie, Rolv T.; Jugessur, Astanand
Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes
Although several lung cancer susceptibility loci have been identified, much of the heritability for lung cancer remains unexplained. Here...
McKay, James D; Hung, Rayjean J; Han, Younghun; Zong, Xuchen; Carreras-Torres, Robert; Christiani, David C; Caporaso, Neil E; Johansson, Mattias; Xiao, Xiangjun; Li, Yafang; Byun, Jinyoung ...
Copy number variation, increased gene expression, and molecular mechanisms of neurofascin in lung cancer
Metastasis and cell adhesion are key aspects of cancer progression. Neurofascin (NFASC) is a member of the immunoglobulin superfamily of ...
Samulin-Erdem, Johanna Maria; Arnoldussen, Yke Jildouw; Skaug, Vidar; Haugen, Aage; Zienolddiny, Shanbeh
Genetic predictors of recovery in low back and lumbar radicular pain
Previous data suggest that persistent back pain may be associated with genetic variability. In this study, we assessed the correlation be...
Bjorland, Siri; Røe, Cecilie; Moen, Aurora Lie; Schistad, Ellina Iordanova; Aqsa, Mahmood; Gjerstad, Johannes
Rotating night work, lifestyle factors, obesity and promoter methylation in BRCA1 and BRCA2 genes among nurses and midwives
Some recent evidence suggests that environmental and lifestyle factors may modify DNA methylation. We hypothesized that rotating night wo...
Peplonska, Beata; Bukowska, Agnieszka; Wieczorek, Edyta; Przybek, Monika; Zienolddiny, Shanbeh; Reszka, Edyta
Ukjente genvarianter påvirker lungekreft
Resultater fra en stor multinasjonal studie der STAMI deltok ble nylig publisert i det prestisjetunge tidsskriftet Nature Genetics. Biolo...
Ny doktorgrad: FOXA-gener og lungekreft
Stipendiat Audun Trygge Haugen Bersaas vil den 2. juni forsvare sin avhandling for graden philosophiae doctor (ph.d.) på Statens arbeidsm...
High birth weight and perinatal mortality among siblings: A register based study in Norway, 1967-2011
Background: Perinatal mortality according to birth weight has an inverse J-pattern. Our aim was to estimate the influence of familial fac...
Kristensen, Petter; Keyes, Katherine M.; Susser, Ezra; Corbett, Karina; Mehlum, Ingrid Sivesind; Irgens, Lorentz M.
Genes associated with persistent lumbar radicular pain; a systematic review
Background: The aim of the present study was to provide an overview of the literature addressing the role of genetic factors and biomarke...
Bjorland, Siri; Moen, Aurora Lie; Schistad, Ellina Iordanova; Gjerstad, Johannes; Røe, Cecilie
Estrogen receptor expression and gene promoter methylation in non-small cell lung cancer - a short report
Purpose: In the past, anomalous estrogen receptor (ER) regulation has been associated with various lung pathologies, but so far its invol...
Tekpli, Xavier; Skaug, Vidar; Bæra, Rita; Phillips, David H.; Haugen, Aage; Mollerup, Steen Kristen
Common genetic variations in cell cycle and DNA repair pathways associated with pediatric brain tumor susceptibility
Fahmideh, Maral Adel; Lavebratt, Catharina; Schüz, Joachim; Röösli, Martin; Tynes, Tore; Grotzer, Michael; Johansen, Christoffer; Kuehni, Claudia E.; Lannering, Birgitta; Prochazka, Michaela; Schmidt, Lisbeth S. ...
A Two-Gene Prognostic Classifier for Early-Stage Lung Squamous Cell Carcinoma in Multiple Large-Scale and Geographically Diverse Cohorts
Introduction: There are no validated molecular methods that prospectively identify patients with surgically resected lung squamous cell c...
Noro, Rintaro; Ishigame, Teruhide; Walsh, Naomi; Shiraishi, Kouya; Robles, Ana I.; Ryan, Bríd M.; Schetter, Aaron J.; Bowman, Elise D.; Welsh, Judith A.; Seike, Masahiro; Gemma, Akihiko ...