Previous data suggest that persistent back pain may be associated with genetic variability. In this study, we assessed the correlation between 8 genetic polymorphisms (VDR, COL11, MMP1, MMP9, IL-1a, IL-1RN, OPRM1, COMT) and pain recovery in patients with low back pain (LBP) and lumbar radicular pain (LRP). In total, 296 patients with LBP or LRP were followed for 5 years. The patients underwent standardized clinical examination and completed pain and function questionnaires. Univariate linear regression associations with P values ,0.1 were included in the multivariable analysis, adjusting for pain intensity at baseline, age, sex, smoking, body mass index, and LBP or LRP. Pain intensity at 5-year follow-up was associated with VDR rs731236 (B 5 20.5, 95% confidence interval [CI] 20.9 to 20.1, P 5 0.017), MMP9 rs17576 (B 5 0.5, 95% CI 0.1-0.9, P 5 0.022), and OPRM1 rs1799971 (B 5 20.8, 95% CI 21.4 to 20.2, P 5 0.006) in the univariate analyses. MMP9 rs17576 and OPRM1 rs1799971 remained significant (B 5 0.4, 95% CI 0.05-0.8, P 5 0.026 and B 5 20.8, 95% CI 21.3 to 20.2, P 5 0.007) in the multivariable model. Thus, the data demonstrated that the rare allele of MMP9 rs17576 was associated with...

Bjorland, Siri; Røe, Cecilie; Moen, Aurora Lie; Schistad, Ellina Iordanova; Aqsa, Mahmood; Gjerstad, Johannes
Pain 158(8): 1456–1460
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