The association between abusive supervision and anxiety in female employees is stronger in carriers of the CRHR1 TAT haplotype

Objective Previous findings suggest that exposure to social stress in the form of abusive supervision may increase the risk of anxiety disorders. In the present study, we examined the link between abusive supervision, the CRHR1 genotype and anxiety. Methods The data was collected through a national survey drawn from the National Central Employee Register by Statistics Norway. A total of 1225 individuals returned both the questionnaire and the saliva kit. Abusive supervision was assessed with 5 items from the Tepper's “Abusive Supervision Scale”. Anxiety was measured by 5 items of the “Hopkins Symptom checklist”. Genotyping with regard to CRHR1 rs7209436 C/T, rs110402 G/A and rs242924 G/T was carried out using Taqman assay, and Phase v.2.1.1 was used to define the CRHR1 haplotype TAT versus CGG. Results The analyses revealed that abusive supervision was associated with anxiety. In particular, we observed a strong effect of abusive supervision on anxiety in female TAT/TAT carriers (p = 0.000). Moreover, using TAT/TAT as a reference, TAT/CGG and CGG/CGG both showed protective effects (p = 0.015, p = 0.001, respectively). Thus, the association between abusive supervision and anxiety was strong among female TAT/TAT carriers was stronger than among female TAT/CGG and female CGG/CGG carriers. No such gene-environment interaction was seen in...