Objectives: The etiology of brain tumors in children and adolescents is largely unknown, and very few environmental risk factors have been identified. The aim of this study was to examine the relationship between pre- or postnatal animal contacts or farm exposures and the risk of childhood brain tumors (CBTs), since infectious agents may pose a risk factor and a proposed mechanism is transferral of infectious agents from animals to humans. Methods: The case–control study conducted in Denmark, Norway, Sweden, and Switzerland included brain tumor cases diagnosed from 2004 to 2008 aged 7–19 years at diagnosis. Three hundred and fifty-two cases (83 % participation rate) were matched to 646 population-based controls (71 % participation rate). Conditional logistic regression was used to estimate odds ratios. Results: Maternal farm residence during pregnancy was inversely related to all CBTs combined (adjusted odds ratio (aOR) = 0.40, 95 % confidence interval (CI) = 0.19–0.88), as was the child’s farm residence but not statistically significantly so (aOR = 0.57, 95 % CI = 0.28–1.17). Exposure to animals was in general not related to CBT risk except postnatal contact with birds showing reduced aORs of all CBTs (0.67, 95 % CI = 0.46–0.97) and primitive neuroectodermal tumor...

Christensen, Jeppe Schultz; Mortensen, Laust H.; Röösli, Martin; Feychting, Maria; Tynes, Tore; Andersen, Tina Veje; Schmidt, Lisbeth Samsø; Poulsen, Aslak Harbo; Aydin, Denis; Kuehni, Claudia E.; Prochazka, Michaela; Lannering, Birgitta; Klæbo, Lars; Eggen, Tone; Schüz, Joachim
Cancer Causes and Control Kluwer Academic/Plenum Publishers, Cancer Causes and Control 23(9): 1463–1473
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