Prosjekt 2012–2016

Arbeid, gener og smerte

The purpose of the proposed project is to examine the interaction between genetics, MRI findings, gender, and work factors with regard to low back pain, workplace absenteeism and disability pensioning.

In this project we will take advantage of our recently established biobank at the National Institute of Occupational Health (NIOH) consisting of 300 Norwegian subjects, which in the period 2009-2010 were treated at Oslo University Hospital (OUS) or Haukeland University Hospital (HUS) for low back pain and sciatica.

A combination of health data from the hospital record, DNA, MRI and pain scores from questionnaires as well as data from health registers at Statistics Norway (SSB), i.e. the «FD-Trygd» database, will be used. To better describe the phenotype of each individual, the protein levels in serum will be analyzed in collaboration with Uppsala University Hospital. The project also includes in-vivo lab experiments, cell-culture work and analyses of microRNA.

Translation of knowledge from basic neuroscience into applied research as described here may be important for future prevention of long lasting pain, workplace absenteeism and disability pensioning.

Eksterne samarbeidspartnere

Cecilie Røe, Department of Physical Medicine and Rehabilitation, Oslo University Hospital (OUS) 
Jaro Karppinen, University of Oulu and Finnish Institute of Occupational Health, Finland 

Finansiering

Prosjektet mottar økonomiske forskningsbidrag fra:
Helse Sørøst http://www.helse-sorost.no/Sider/side.aspx

Publikasjoner

[1] Dominguez CA, Kalliomaki M, Gunnarsson U, Moen A, Sandblom G, Kockum I, Lavant E, Olsson T, Nyberg F, Rygh LJ, Roe C, Gjerstad J, Gordh T, Piehl F. The DQB1 *03:02 HLA haplotype is associated with increased risk of chronic pain after inguinal hernia surgery and lumbar disc herniation. Pain 2013; 154(3): 427-433.
[2] Egeland NG, Moen A, Pedersen LM, Brisby H, Gjerstad J. Spinal nociceptive hyperexcitability induced by experimental disc herniation is associated with enhanced local expression of Csf1 and FasL. Pain 2013; 154(9): 1743-1748.
[3] Eriksen GS, Jacobsen LM, Mahmood A, Pedersen LM, Gjerstad J. Inhibition of fatty acid amide hydrolase (FAAH) reduces spinal nociceptive responses and expression of spinal long-term potentiation (LTP). Brain research bulletin 2012; 87(2-3): 234-237.
[4] Hasvik E, Iordanova Schistad E, Grovle L, Julsrud Haugen A, Roe C, Gjerstad J. Subjective health complaints in patients with lumbar radicular pain and disc herniation are associated with a sex – OPRM1 A118G polymorphism interaction: a prospective 1-year observational study. BMC musculoskeletal disorders 2014; 15: 161.
[5] Jacobsen LM, Schistad EI, Storesund A, Pedersen LM, Espeland A, Rygh LJ, Roe C, Gjerstad J. The MMP1 rs1799750 2G allele is associated with increased low back pain, sciatica, and disability after lumbar disk herniation. The Clinical journal of pain 2013; 29(11): 967-971.
[6] Jacobsen LM, Schistad EI, Storesund A, Pedersen LM, Rygh LJ, Roe C, Gjerstad J. The COMT rs4680 Met allele contributes to long-lasting low back pain, sciatica and disability after lumbar disc herniation. European journal of pain 2012; 16(7): 1064-1069.
[7] Matre D, Olsen MB, Jacobsen LM, Klein T, Gjerstad J. Induction of the perceptual correlate of human long-term potentiation (LTP) is associated with the 5-HTT genotype. Brain research 2013; 1491: 54-59.
[8] Moen A, Schistad EI, Rygh LJ, Roe C, Gjerstad J. Role of IL1A rs1800587, IL1B rs1143627 and IL1RN rs2234677 genotype regarding development of chronic lumbar radicular pain; a prospective one-year study. PloS one 2014; 9(9): e107301.
[9] Olsen MB, Jacobsen LM, Schistad EI, Pedersen LM, Rygh LJ, Roe C, Gjerstad J. Pain intensity the first year after lumbar disc herniation is associated with the A118G polymorphism in the opioid receptor mu 1 gene: evidence of a sex and genotype interaction. The Journal of neuroscience : the official journal of the Society for Neuroscience 2012; 32(29): 9831-9834.
[10] Schistad EI, Espeland A, Pedersen LM, Sandvik L, Gjerstad J, Roe C. Association between baseline IL-6 and 1-year recovery in lumbar radicular pain. European journal of pain 2014; 18(10): 1394-1401.
[11] Schistad EI, Espeland A, Rygh LJ, Roe C, Gjerstad J. The association between Modic changes and pain during 1-year follow-up in patients with lumbar radicular pain. Skeletal radiology 2014; 43(9): 1271-1279.
[12] Schistad EI, Jacobsen LM, Roe C, Gjerstad J. The interleukin-1alpha gene C>T polymorphism rs1800587 is associated with increased pain intensity and decreased pressure pain thresholds in patients with lumbar radicular pain. The Clinical journal of pain 2014; 30(10): 869-874.