Kreft

Copy number variation, increased gene expression, and molecular mechanisms of neurofascin in lung cancer

Metastasis and cell adhesion are key aspects of cancer progression. Neurofascin (NFASC) is a member of the immunoglobulin superfamily of ...

Samulin-Erdem, Johanna Maria; Arnoldussen, Yke Jildouw; Skaug, Vidar; Haugen, Aage; Zienolddiny, Shanbeh

Mechanisms of breast cancer risk in shift workers. Association of telomere shortening with the duration and intensity of night work

Occupational factors such as shiftwork and especially night work that involves disruption of the circadian rhythm may contribute to incre...

Samulin-Erdem, Johanna Maria; Notø, Heidi Ødegaard; Skare, Øivind; Lie, Jenny-Anne Sigstad; Petersen-Øverleir, Marte; Reszka, Edyta; Peplonska, Beata; Zienolddiny, Shanbeh

Prenatal and postnatal medical conditions and the risk of brain tumors in children and adolescents: An international multicenter case-control study

Background: Previous studies have evaluated the effect of medical diagnostic radiation on brain tumors. Recent cohort studies have report...

Tettamanti, Giorgio; Shu, Xiaochen; Fahmideh, Maral Adel; Schüz, Joachim; Röösli, Martin; Tynes, Tore; Grotzer, Michael; Johansen, Christoffer; Klæboe, Lars Hind Bakken; Kuehni, Claudia; Lannering, Birgitta ...

Estrogen receptor expression and gene promoter methylation in non-small cell lung cancer - a short report

Purpose: In the past, anomalous estrogen receptor (ER) regulation has been associated with various lung pathologies, but so far its invol...

Tekpli, Xavier; Skaug, Vidar; Bæra, Rita; Phillips, David H.; Haugen, Aage; Mollerup, Steen Kristen

Common genetic variations in cell cycle and DNA repair pathways associated with pediatric brain tumor susceptibility

Fahmideh, Maral Adel; Lavebratt, Catharina; Schüz, Joachim; Röösli, Martin; Tynes, Tore; Grotzer, Michael; Johansen, Christoffer; Kuehni, Claudia E.; Lannering, Birgitta; Prochazka, Michaela; Schmidt, Lisbeth S. ...

Parental occupational exposure to heavy metals and welding fumes and risk of testicular germ cell tumors in offspring: A registry-based case-control study

Background: Data are scarce on the association between prenatal/preconception environmental exposure and testicular germ cell tumor (TGCT...

Togawa, Kayo; Le Cornet, Charlotte; Feychting, Maria; Tynes, Tore; Pukkala, Eero; Hansen, Johnni; Olsson, Ann; Dalton, Susanne Oksbjerg; Nordby, Karl-Christian; Uuksulainen, Sanni; Wiebert, Pernilla ...

A Two-Gene Prognostic Classifier for Early-Stage Lung Squamous Cell Carcinoma in Multiple Large-Scale and Geographically Diverse Cohorts

Introduction: There are no validated molecular methods that prospectively identify patients with surgically resected lung squamous cell c...

Noro, Rintaro; Ishigame, Teruhide; Walsh, Naomi; Shiraishi, Kouya; Robles, Ana I.; Ryan, Bríd M.; Schetter, Aaron J.; Bowman, Elise D.; Welsh, Judith A.; Seike, Masahiro; Gemma, Akihiko ...

Characteristics of breakthrough cancer pain and its influence on quality of life in an international cohort of patients with cancer

Objectives: Breakthrough cancer pain (BTP) represents a treatment challenge. Objectives were to examine the prevalence and characteristic...

Hjermstad, Marianne Jensen; Kaasa, Stein; Caraceni, Augusto; Loge, Jon Håvard; Pedersen, Tore; Haugen, Dagny Faksvåg; Aass, Nina Kathrine

Genetic risk can be decreased. Quitting smoking decreases and delays lung cancer for smokers with high and low CHRNA5 risk genotypes. A meta-analysis

Background: Recent meta-analyses show that individuals with high risk variants in CHRNA5 on chromosome 15q25 are likely to develop lung c...

Chen, Li-Shiun; Baker, Timothy; Hung, Rayjean J.; Horton, Amy; Culverhouse, Robert; Hartz, Sarah; Saccone, Nancy; Cheng, Iona; Deng, Bo; Han, Younghun; Hansen, Helen M. ...

Prostate cancer and the unfolded protein response

The endoplasmic reticulum (ER) is an essential organelle that contributes to several key cellular functions, including lipogenesis, gluco...

Storm, Margrethe Larsdatter; Sheng, Xia; Arnoldussen, Yke Jildouw; Saatcioglu, Fahri

Occupation and relative risk of cutaneous squamous cell carcinoma (cSCC). A 45-year follow-up study in 4 Nordic countries

Background: The age-adjusted incidence of cutaneous squamous cell carcinoma (cSCC) in the Nordic countries has increased during the last ...

Alfonso, Jose Hernan; Martinsen, Jan Ivar; Pukkala, Eero; Weiderpass, Elisabete; Tryggvadottir, Laufey; Nordby, Karl-Christian; Kjærheim, Kristina

Epithelial-mesenchymal transition and FOXA genes during tobacco smoke carcinogen induced transformation of human bronchial epithelial cells

Lung cancer is largely an environmentally caused disease with poor prognosis. An in vitro transformation model of human bronchial epithel...

Bersaas, Audun Trygge Haugen; Arnoldussen, Yke Jildouw; Sjøberg, Mari; Haugen, Aage; Mollerup, Steen Kristen

Physico-chemical properties and biological effects of diesel and biomass particles

Diesel combustion and solid biomass burning are the major sources of ultrafine particles (UFP) in urbanized areas. Cardiovascular and pul...

Longhin, Eleonora; Gualtieri, Maurizio; Capasso, Lauro; Bengalli, Rossella; Mollerup, Steen Kristen; Holme, Jørn Andreas; Øvrevik, Johan; Casadei, Simone; Di Benedetto, Christiano; Parenti, Paolo; Camatini, Marina

Assessment of occupational exposure to pesticides in a pooled analysis of agricultural cohorts within the AGRICOH consortium

Background This paper describes methods developed to assess occupational exposure to pesticide active ingredients and chemical groups, ha...

Brouwer, Maartje; Schinasi, Leah; Freeman, Laura E. Beane; Baldi, Isabelle; Lebailly, Pierre; Ferro, Gilles; Nordby, Karl-Christian; Schüs, Joachim; Leon, Maria E.; Kromhout, H

Loss of MKK3 and MK2 copy numbers in non-small cell lung cancer

Identification of genetic alterations in members of the p38 mitogen-activated protein kinase (MAPK) pathway is important as these protein...

Samulin-Erdem, Johanna Maria; Skaug, Vidar; Haugen, Aage; Zienolddiny, Shanbeh

Mutations in TP53 increase the risk of SOX2 copy number alterations and silencing of TP53 reduces SOX2 expression in non-small cell lung cancer

Background: Amplifications of the transcription factor, SRY (sex determining region Y)-box 2 (SOX2), are common in non-small cell lung ca...

Samulin-Erdem, Johanna Maria; Skaug, Vidar; Bakke, Per S.; Gulsvik, Amund; Haugen, Aage; Zienolddiny, Shanbeh

A multinational case-control study on childhood brain tumours, anthropogenic factors, birth characteristics and prenatal exposures: A validation of interview data

Little is known about the aetiology of childhood brain tumours. We investigated anthropometric factors (birth weight, length, maternal ag...

Vienneau, Danielle; Infanger, Denis; Feychting, Maria; Schüz, Joachim; Schmidt, Lisbeth Samsø; Poulsen, Aslak Harbo; Tettamanti, Giorgio; Klæboe, Lars Hind Bakken; Kuehni, Claudia E.; Tynes, Tore; Von der Weid, Nicolas ...

Testicular germ cell tumours and parental occupational exposure to pesticides: A register-based case-control study in the nordic countries (NORD-TEST study)

Abstract: Objectives A potential impact of exposure to endocrine disruptors, including pesticides, during intrauterine life, has been hyp...

Le Cornet, Charlotte; Fervers, Beatrice; Dalton, Susanne Oksbjerg; Feychting, Maria; Pukkala, Eero; Tynes, Tore; Hansen, Johnni; Nordby, Karl-Christian; Béranger, Rémi; Kauppinen, Timo; Uuksulainen, Sanni ...

Tolerability and pharmacokinetic profile of a novel benzene-poly-carboxylic acids complex with cis-diammineplatinum (II) dichloride in dogs with malignant mammary tumours

The pharmacokinetic profile, tolerability and efficacy of benzene‐poly‐carboxylic acids complex with cis‐diammineplatinum (II) dichloride...

Kristiansen, Veronica; Dewi, Sagita; Horsberg, Tor Einar; Jonasdottir, Thora Johanna; Moe, Lars; Berlinger, Balazs; Lindkær-Jensen, Steen; Larsen, Stig

An integrated prognostic classifier for Stage I lung adenocarcinoma based on mRNA, microRNA, and DNA methylation biomarkers

Introduction: Up to 30% stage I lung cancer patients suffer recurrence within 5 years of curative surgery. We sought to improve existing ...

Robles, Ana I.; Arai, Eri; Mathé, Ewy A.; Okayama, Hirokazu; Schetter, Aaron J.; Brown, Derek; Petersen, David; Bowman, Elise D.; Noro, Rintaro; Welsh, Judith A.; Edelman, Daniel C. ...

Divergent androgen regulation of unfolded protein response pathways drives prostate cancer

The unfolded protein response (UPR) is a homeostatic mechanism to maintain endoplasmic reticulum (ER) function. The UPR is activated by v...

Sheng, Xia; Arnoldussen, Yke Jildouw; Storm, Margrethe Larsdatter; Tesikova, Martina; Nenseth, Hatice Zeynep; Zhao, Sen; Fazli, Ladan; Rennie, Paul S.; Risberg, Bjørn Åke; Wæhre, Haakon; Danielsen, Håvard Emil ...

CCDC26, CDKN 2BAS, RTEL1 and TERT Polymorphisms in pediatric brain tumor susceptibility

Background: Chronic Fatigue Syndrome (CFS) is a common and disabling condition in adolescence with few treatment options. A central featu...

Fahmideh, Maral Adel; Lavebratt, Catharina; Schüz, Joachim; Röösli, Martin; Tynes, Tore; Grotzer, Michael; Johansen, Christoffer; Kuehni, Claudia E.; Lannering, Birgitta; Prochazka, Michaela; Schmidt, Lisbeth S. ...

CHRNA5 risk variant predicts delayed smoking cessation and earlier lung cancer diagnosis—A meta-analysis

Background: Recent meta-analyses show strong evidence of associations among genetic variants in CHRNA5 on chromosome 15q25, smoking quant...

Chen, Li-Shiun; Hung, Rayjean J.; Baker, Timothy B.; Horton, Amy; Culverhouse, Rob; Saccone, Nancy; Cheng, Iona; Deng, Bo; Han, Younghun; Hansen, Helen M.; Horsman, Janet ...