Elimination and reduction of causative or contributing occupational exposures effectively prevent occupational dermatoses. Thus, full prevention is achievable with a legislation framework for elimination, substitution, and reduction of skin irritants, urticariogens, allergens, and carcinogens at the workplace. Measures to maintain the natural protective function of the skin barrier are pivotal to keep healthy skin among workers. Moreover, early recognition, diagnosis, and treatment of work-related skin problems will avoid chronification, and a severe and recalcitrant course with high social costs. This chapter will present evidence-based standards for the prevention of occupational dermatoses from the legislative level to daily medical practice.