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Silica dust exposure increases risk for rheumatoid arthritis. A Swedish National Registry Case–Control Study

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Publisert

  • 2021

Objective: Rheumatoid arthritis (RA) is an inflammatory disease with unknown etiology. This study examines if silica dust exposure increases the risk for seropositive and seronegative RA. Methods: A nationwide registry case–control study was conducted that included all cases of RA in Sweden between 2005 and 2016. In total, 31,139 cases with two matched controls were included. A JEM was used to estimate exposure. Results: Silica dust exposure was associated with a statistically significant increase in odds ratio (OR) for seropositive (OR 1.22, 95% CI 1.05 to 1.40) and seronegative (OR 1.23, 95% CI 1.04 to 1.46) RA among men. Conclusion: This study found an increased OR for RA in silica-exposed men. The OR was equal for seropositive and seronegative RA. These findings further support the hypothesis that silica dust may be a trigger for RA.

Wrangel, Oscar; Graff, Pål; Bryngelsson, Ing-Liss; Fornander, Louise; Wiebert, Pernilla; Vihlborg, Per
Journal of Occupational and Environmental Medicine 63(11): 951–955
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