In this project we will take advantage of our recently established biobank at the National Institute of Occupational Health (NIOH) consisting of 300 Norwegian subjects, which in the period 2009-2010 were treated at Oslo University Hospital (OUS) or Haukeland University Hospital (HUS) for low back pain and sciatica.
A combination of health data from the hospital record, DNA, MRI and pain scores from questionnaires as well as data from health registers at Statistics Norway (SSB), i.e. the “FD-Trygd” database, will be used. To better describe the phenotype of each individual, the protein levels in serum will be analyzed in collaboration with Uppsala University Hospital. The project also includes in-vivo lab experiments, cell-culture work and analyses of microRNA.
Translation of knowledge from basic neuroscience into applied research as described here may be important for future prevention of long lasting pain, workplace absenteeism and disability pensioning.