{"id":3589,"date":"2025-01-30T10:06:50","date_gmt":"2025-01-30T09:06:50","guid":{"rendered":"https:\/\/stami.no\/en\/?post_type=project&p=3589"},"modified":"2025-01-30T10:06:51","modified_gmt":"2025-01-30T09:06:51","slug":"development-of-in-vitro-methods-for-risk-assessment-of-skin-sensitization-due-to-mixture-exposures-from-irritants-and-allergens-skinsenmix","status":"publish","type":"project","link":"https:\/\/stami.no\/en\/project\/development-of-in-vitro-methods-for-risk-assessment-of-skin-sensitization-due-to-mixture-exposures-from-irritants-and-allergens-skinsenmix\/","title":{"rendered":"Development of In Vitro Methods for Risk Assessment of Skin Sensitization due to Mixture Exposures \u00a0from Irritants and Allergens \u2013 SKINSENMIX"},"content":{"rendered":"
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The primary objective of this project is to contribute to the development of new risk assessment methods for skin mixture exposure to irritants and allergens. Such methods are necessary to prevent skin issues such as irritation, skin allergy, and eczema among at-risk workers and the general population.<\/p>\n\n\n<\/div>\n\n\n\n

Background<\/h2>\n\n\n\n

Approximately 34 percent of Norwegian employees report skin contact with chemicals, according to data from NOA at STAMI<\/a>. Chemicals encountered in the workplace often consist of a mixture of both irritants and allergens, but we do not fully understand whether this mixture exposure poses a higher risk for irritation and\/or allergy, and there are currently no risk assessment methods that can adequately assess this. Such risk assessment methods are necessary to protect at-risk workers and the general population.<\/p>\n\n\n\n

Traditionally, chemical risk assessment has largely relied on animal studies. A primary objective of PARC is to replace these studies with advanced and targeted cell culture\/in vitro models (“New Approach Methods – NAMs”). In the EU, there is ongoing work to ensure this approach is applied when assessing the risk of skin irritation and\/or allergy. However, these in vitro models have not been investigated in relation to mixture exposures to irritants and allergens in the workplace. This project aims to generate new knowledge on this topic.<\/p>\n\n\n\n

Objectives of the Project<\/h2>\n\n\n\n

The main goal of the project is to investigate the suitability of in vitro models for risk assessment of exposure to mixtures of irritants and allergens through:<\/p>\n\n\n\n

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  1. Identifying knowledge gaps in the risk assessment of mixture exposure to chemical substances that can cause skin irritation and contact allergy.<\/li>\n\n\n\n
  2. Further developing existing in vitro methods for risk assessment of mixture exposure to chemical substances that can cause skin irritation and contact allergy. This will be carried out by evaluating the applicability and suitability of NAMs, three-dimensional skin models, and in vivo skin models for risk assessment of mixture exposure to allergens and irritants.<\/li>\n<\/ol>\n\n\n\n

    Project leaders: <\/strong>
    Jose Hern\u00e1n Alfonso
    Steen Mollerup<\/p>\n\n\n\n

    Project group members:<\/strong>
    Shan Narui
    Mayes Alswady-Hoff
    \u00d8ivind Skare<\/p>\n\n\n\n

    External Collaborators:<\/strong><\/p>\n\n\n\n